![]() ![]() ![]() After several days, the dosage may be increased to 120 mg (given as a single 120 mg tablet or as two 60 mg tablets) once daily. The recommended starting dose of IMDUR Tablets is 30 mg (given as a single 30 mg tablet or as 1/2 of a 60 mg tablet) or 60 mg (given as a single tablet) once daily. The onset of action of oral isosorbide mononitrate is not sufficiently rapid for this product to be useful in aborting an acute anginal episode. IMDUR Tablets are indicated for the prevention of angina pectoris due to coronary artery disease. The relative importance of preload reduction, afterload reduction, and coronary dilatation remains undefined. Dilatation of the coronary arteries also occurs. Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure and mean arterial pressure (afterload). ![]() Dilatation of the veins promotes peripheral pooling of blood, decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure and pulmonary capillary wedge pressure (preload). The principal pharmacological action of ISMN and all organic nitrates in general is relaxation of vascular smooth muscle, producing dilatation of peripheral arteries and veins, especially the latter. The IMDUR product is an oral extended-release formulation of ISMN, the major active metabolite of isosorbide dinitrate most of the clinical activity of the dinitrate is attributable to the mononitrate. Isosorbide mononitrate is freely soluble in water, ethanol, methanol, chloroform, ethyl acetate, and dichloromethane. ISMN is a white, crystalline, odorless compound which is stable in air and in solution, has a melting point of about 90☌, and an optical rotation of +144° (2% in water, 20☌). The chemical name for ISMN is 1,4:3,6-dianhydro-,D-glucitol 5-nitrate The molecular formula of ISMN is C6 H9 NO6 and the molecular weight is 191.14. In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, hydrogenated castor oil, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose and talc. IMDUR® Tablets, for oral administration, contain either 30 mg, 60 mg or 120 mg of isosorbide mononitrate in an extended-release formulation. Isosorbide mononitrate (ISMN), an organic nitrate and the major biologically active metabolite of isosorbide dinitrate (ISDN), is a vasodilator with effects on both arteries and veins. IMDUR- isosorbide mononitrate tablet, extended release IODOQQUINOL-HYDROCORTISONE-POLYSAC ALOE. ![]()
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